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References   References 50  
Type : Journal
Research teams : Winston-Salem - Wake Forest School of Medicine
Authors : Fleming RA, Olsen DJ, Savage PD, Fox JL.
Title : Stability of ondansetron hydrochloride and cyclophosphamide in injectable solutions.
Reference : Am J Health-Syst Pharm ; 52: 514-516. 1995
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
List of drugs
injectionCyclophosphamide Anticancer drug
Compatible 0,3 mg/ml + injectionOndansetron hydrochloride 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionOndansetron hydrochloride 0,4 mg/ml + NaCl 0,9% or Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 0,05 mg/ml + injectionCyclophosphamide 0,3 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0,4 mg/ml + injectionCyclophosphamide 2 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C-25°C Light
injection Ondansetron hydrochloride 0,05 mg/ml
injection Cyclophosphamide 0,3 mg/ml
4 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C-25°C Light
injection Ondansetron hydrochloride 0,4 mg/ml
injection Cyclophosphamide 2 mg/ml
4 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Light
injection Ondansetron hydrochloride 0,05 mg/ml
injection Cyclophosphamide 0,3 mg/ml
8 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Light
injection Ondansetron hydrochloride 0,4 mg/ml
injection Cyclophosphamide 2 mg/ml
8 Day
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