Last update :
27/01/2022
References   References 4628  
Type : Journal
Web link : https://doi.org/10.3390/ph14090943.

Research teams : Modena - Pharmaceutical Department, Azienda USL of Modena, Italy
Authors : Iudicello A, Genovese F, Strusi V, Dominici M, Ruozi B.
Title : Development and Validation of a New Storage Procedure to Extend the In-Use Stability of Azacitidine in Pharmaceutical Formulations.
Reference : Pharmaceuticals ; 14, 943. 2021

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionAzacitidine Anticancer drug
Stability in solutions Polypropylen Syringe Water for Injection (4°C) 25 mg/ml 2-8°C Protect from light
48 Hour
Conflicting data

  Mentions Légales