Last update :
15/10/2021
References   References 4584  
Type : Journal
Web link : http:// dx. doi. org/ 10. 1136/ ejhpharm- 2021- 002748

Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Gilliot S, Henry H, Carta N, Genay S, Barthélémy C, Décaudin B, Odou P.
Title : Long-term stability of 10 mg/mL dobutamine injectable solutions in 5% dextrose and normal saline solution stored in polypropylene syringes and cyclic-oleofin- copolymer vials.
Reference : EJHP 2021

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
InjectionDobutamine hydrochloride Cardiotonic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 10 mg/ml 2-8°C Protect from light
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml -25 >> -15°C Protect from light
90 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml 23-27°C Protect from light
30 Day
Stability in solutions Polypropylen Syringe Glucose 5% 10 mg/ml -25 >> -15°C Protect from light
21 Day
Stability in solutions AT-Closed vial® NaCl 0,9% or Glucose 5% 10 mg/ml -25 >> -15°C Protect from light
365 Day
Stability in solutions AT-Closed vial® NaCl 0,9% or Glucose 5% 10 mg/ml 2-8°C Protect from light
365 Day
Stability in solutions AT-Closed vial® NaCl 0,9% or Glucose 5% 10 mg/ml 23-27°C Protect from light
365 Day

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