Last update :
18/04/2024
References   References 4522  
Type : Journal

Research teams : Louvain - Laboratory for Pharmaceutical Chemistry and Drug Analysis
Authors : Lin Q, Van Schepdael A, Adams E.
Title : Six months stability investigation of sufentanil and ropivacaine/levobupivacaine admixtures in plastic container by LC-UV.
Reference : J Pharm Biomed Anal 2020

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
No visual inspection

List of drugs
InjectionLevobupivacaine hydrochloride Local anesthetic
Compatible 1.25 mg/ml + InjectionSufentanil citrate 0.00075 mg/ml + Sodium chloride 0,9%
InjectionRopivacain hydrochloride Local anesthetic
Compatible 1.2 mg/ml + InjectionSufentanil citrate 0.00075 mg/ml + Sodium chloride 0,9%
InjectionSufentanil citrate Analgesic
Compatible 0.00075 mg/ml + InjectionLevobupivacaine hydrochloride 1.25 mg/ml + Sodium chloride 0,9%
Compatible 0.00075 mg/ml + InjectionRopivacain hydrochloride 1.2 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
Injection Ropivacain hydrochloride 1,2 mg/ml
Injection Sufentanil citrate 0,00075 mg/ml
180 Day
Polypropylene Sodium chloride 0,9% 4°C Not specified
Injection Sufentanil citrate 0,001 mg/ml
Injection Levobupivacaine hydrochloride 1,25 mg/ml
180 Day
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Sufentanil citrate 0,001 mg/ml
Injection Levobupivacaine hydrochloride 1,25 mg/ml
180 Day
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Sufentanil citrate 0,00075 mg/ml
Injection Ropivacain hydrochloride 1,2 mg/ml
180 Day

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