Last update :
27/11/2024
References   References 444  
Type : Journal

Research teams : Raritan - Johnson & Johnson Pharmaceutical Research & Development
Authors : Bornstein M, Kao SH, Mercorelli M, Verma S.
Title : Stability of an ofloxacin injection in various infusion fluids.
Reference : Am J Hosp Pharm ; 49: 2756-2760. 1992

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
injectionOfloxacin Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 0,4 & 4 mg/ml -20°C Protect from light
182 Day
Stability in solutions Polyvinyl chloride Water for Injection 0,4 & 4 mg/ml 24°C Protect from light
3 Day
Stability in solutions Polyvinyl chloride Water for Injection 0,4 & 4 mg/ml 5°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 & 4 mg/ml -20°C Protect from light
182 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 & 4 mg/ml 24°C Protect from light
3 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 & 4 mg/ml 5°C Protect from light
14 Day

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