Last update :
03/05/2024
References   References 4298  
Type : Journal
Web link : https://onlinelibrary.wiley.com/doi/abs/10.1002/bmc.4471

Research teams : Porto Alegre - Pharmacy School of Federal University of Rio Grande do Sul
Authors : Fabio de Souza Barbosa F, Capra Pezzi L, Tsao M, Franco de Oliveira T, Dias Macedo S.M, Schapoval E.E.S, Mendez A.S.L.
Title : Stability and degradation products of imipenem applying High-Resolution Mass Spectrometry: an analytical study focused on solutions for infusion.
Reference : Biomed Chromatogr ; 33, 4:e4471 2019

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified
No visual inspection

List of drugs
InjectionImipenem - cilastatin sodium Antibiotic
Stability in solutions Not specified NaCl 0,9% or Glucose 5% 5 mg/ml 2-8°C Not specified
8 Hour
Stability in solutions Not specified NaCl 0,9% or Glucose 5% 5 mg/ml 23-27°C Not specified
4 Hour

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