Last update :
27/11/2024
References   References 419  
Type : Journal

Research teams : Gainesville - University of Florida, College of Pharmacy
Authors : James MJ, Riley CM.
Title : Stability of intravenous admixtures of aztreonam and clindamycin phosphate.
Reference : Am J Hosp Pharm ; 42: 1984-1986. 1985

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
injectionAztreonam Antibiotic
Compatible 20 mg/ml + injectionClindamycin phosphate 6 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 20 mg/ml + injectionClindamycin phosphate 3 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 10 mg/ml + injectionClindamycin phosphate 3 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 10 mg/ml + injectionClindamycin phosphate 6 mg/ml + NaCl 0,9% or Glucose 5%
injectionClindamycin phosphate Antibiotic
Compatible 6 mg/ml + injectionAztreonam 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionAztreonam 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionAztreonam 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 6 mg/ml + injectionAztreonam 10 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 22°C-23°C Not specified
injection Aztreonam 10 & 20 mg/ml
injection Clindamycin phosphate 3 & 6 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Aztreonam 10 & 20 mg/ml
injection Clindamycin phosphate 3 & 6 mg/ml
7 Day

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