Last update :
19/11/2024
References   References 4116  
Type : Journal

Research teams : Hubei - Dongfeng Hospital, Hubei University of Medicine
Authors : Chen F, Zhu J, Li B, Yuan F, Wang K.
Title : Stability of tramadol with three 5-HT3 receptor antagonists in polyolefin bags for patient-controlled delivery systems.
Reference : Drug Design Dev Ther ;10:1869-1875 2016

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionGranisetron hydrochloride Antiemetic
Compatible 0.06 mg/ml + injectionTramadol hydrochloride 10 mg/ml + Sodium chloride 0,9%
injectionOndansetron hydrochloride Antiemetic
Compatible 0.08 mg/ml + injectionTramadol hydrochloride 10 mg/ml + Sodium chloride 0,9%
injectionTramadol hydrochloride Analgesic
Compatible 10 mg/ml + injectionGranisetron hydrochloride 0.06 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionOndansetron hydrochloride 0.08 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionTropisetron hydrochloride 0.05 mg/ml + Sodium chloride 0,9%
injectionTropisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + injectionTramadol hydrochloride 10 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyolefine Sodium chloride 0,9% 25°C Not specified
injection Tramadol hydrochloride 10 mg/ml
injection Ondansetron hydrochloride 0,08 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 25°C Not specified
injection Tramadol hydrochloride 10 mg/ml
injection Granisetron hydrochloride 0,06 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 25°C Not specified
injection Tramadol hydrochloride 10 mg/ml
injection Tropisetron hydrochloride 0,05 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 4°C Not specified
injection Tramadol hydrochloride 10 mg/ml
injection Ondansetron hydrochloride 0,08 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 4°C Not specified
injection Tramadol hydrochloride 10 mg/ml
injection Granisetron hydrochloride 0,06 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 4°C Not specified
injection Tramadol hydrochloride 10 mg/ml
injection Tropisetron hydrochloride 0,05 mg/ml
14 Day

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