Bibliographie - 4011 - Stabilis 4.0

Last update :
18/07/2024

References 4011

Type :

Journal

Web link :

http://dx.doi.org/10.1136/ejhpharm-2016-001038

Research teams :

Kiel - Christian-Albrechts- University Kiel, Pharmaceutical Institute

Authors :

Gersonde F, Eisend S, Haake N, Kunze T.

Title :

Physicochemical compatibility and emulsion stability of propofol with commonly used analgesics and sedatives in an intensive care unit.

Reference :

EJHP 2016;0:1-11 2016

Level of Evidence :

Physical stability :

Chemical stability :

High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)

High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)

Stability defined as 90% of the initial concentration

Other methods :

Comments :

Stability indicating capability inadequately assessed

List of drugs

Clonidine hydrochloride

0.001 >> 0.015 mg/ml

Propofol

1.8 >> 18.2 mg/ml

Dexmedetomidine

0.4 >> 18.2 µg/ml

Propofol

1.8 >> 18.2 mg/ml

Ketamine hydrochloride

2.3 >> 22.7 mg/ml

Propofol

1.8 >> 18.2 mg/ml

Lormetazepam

0.004 >> 0.11 mg/ml

Propofol

1.8 >> 18.2 mg/ml

Midazolam hydrochloride

	1.8 & 3.3 mg/ml	+ Propofol	1.8 & 10 mg/ml	+
	0.3 mg/ml	+ Propofol	18.2 mg/ml	+

Piritramide

	0.5 & 0.9 mg/ml	+ Propofol	1.8 & 10 mg/ml	+
	0.09 mg/ml	+ Propofol	18.2 mg/ml	+

Propofol

1.8 >> 18.2 mg/ml	+ Clonidine hydrochloride	0.001 >> 0.015 mg/ml	+
1.8 >> 18.2 mg/ml	+ Dexmedetomidine	0.4 >> 18.2 µg/ml	+
1.8 >> 18.2 mg/ml	+ Ketamine hydrochloride	2.3 >> 22.7 mg/ml	+
1.8 >> 18.2 mg/ml	+ Lormetazepam	0.004 >> 0.11 mg/ml	+
1.8 & 10 mg/ml	+ Midazolam hydrochloride	1.8 & 3.3 mg/ml	+
18.2 mg/ml	+ Midazolam hydrochloride	0.3 mg/ml	+
1.8 & 10 mg/ml	+ Piritramide	0.5 & 0.9 mg/ml	+
18.2 mg/ml	+ Piritramide	0.09 mg/ml	+
1.8 >> 18.2 mg/ml	+ Remifentanil hydrochloride	4.5 >> 45.5 µg/ml	+
1.8 & 10 mg/ml	+ Sodium oxybate	100 & 181.8 mg/ml	+
18.2 mg/ml	+ Sodium oxybate	18.2 mg/ml	+
1.8 >> 18.2 mg/ml	+ Sufentanil citrate	0.0009 >> 0.03 mg/ml	+

Remifentanil hydrochloride

	pH		pH >7
	4.5 >> 45.5 µg/ml	+ Propofol	1.8 >> 18.2 mg/ml	+

Sodium oxybate

	100 & 181.8 mg/ml	+ Propofol	1.8 & 10 mg/ml	+
	18.2 mg/ml	+ Propofol	18.2 mg/ml	+

Sufentanil citrate

0.0009 >> 0.03 mg/ml

Propofol

1.8 >> 18.2 mg/ml

25°C

Propofol	6,7 mg/ml
Sufentanil citrate	0,0033 mg/ml
Midazolam hydrochloride	1,2 mg/ml

25°C

Propofol	6,7 mg/ml
Sufentanil citrate	0,0033 mg/ml
Piritramide	0,33 mg/ml

25°C

Propofol	5 mg/ml
Sufentanil citrate	0,0075 mg/ml
Midazolam hydrochloride	0,9 mg/ml
Lormetazepam	0,03 mg/ml

25°C

Dexmedetomidine	6,6 µg/ml
Sufentanil citrate	0,01 mg/ml
Propofol	6,7 mg/ml

25°C

Propofol	6,7 mg/ml
Sufentanil citrate	0,01 mg/ml
Clonidine hydrochloride	0,005 mg/ml

25°C

Midazolam hydrochloride	1,2 mg/ml
Remifentanil hydrochloride	1,7 µg/ml
Propofol	6,7 mg/ml

25°C

Propofol	10 mg/ml
Clonidine hydrochloride	0,0075 mg/ml

25°C

Propofol	1,8 mg/ml
Clonidine hydrochloride	0,0136 mg/ml

25°C

Propofol	18 mg/ml
Clonidine hydrochloride	0,00136 mg/ml

25°C

Propofol	18 mg/ml
Dexmedetomidine	1,81 µg/ml

25°C

Propofol	1,8 mg/ml
Dexmedetomidine	18,1 µg/ml

25°C

Propofol	10 mg/ml
Dexmedetomidine	10 µg/ml

25°C

Propofol	10 mg/ml
Ketamine hydrochloride	12,5 mg/ml

25°C

Propofol	1,8 mg/ml
Ketamine hydrochloride	22,7 mg/ml

25°C

Propofol	18 mg/ml
Ketamine hydrochloride	2,27 mg/ml

25°C

Propofol	18 mg/ml
Lormetazepam	0,009 mg/ml

25°C

Propofol	1,8 mg/ml
Lormetazepam	0,09 mg/ml

25°C

Propofol	10 mg/ml
Lormetazepam	0,06 mg/ml

25°C

Propofol	10 mg/ml
Sufentanil citrate	0,015 mg/ml

25°C

Propofol	1,8 mg/ml
Sufentanil citrate	0,027 mg/ml

25°C

Propofol	18 mg/ml
Sufentanil citrate	0,0027 mg/ml

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