Last update :
19/11/2024
References   References 3839  
Type : Journal
Web link : http://www.currenttherapeuticres.com/article/S0011-393X(15)00016-8/abstract

Research teams : San Francisco - Theravance Biopharma
Authors : Gu Z, Parra C, Wong A, Nguyen A, Cheung R, Catalano T.
Title : Post-reconstitution Stability of Telavancin with Commonly Used Diluents and Intravenous Infusion Solutions.
Reference : Current Ther Res ; 77: 105-110. 2015

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
injectionTelavancin hydrochloride Antibiotic
Stability in solutions Glass Water for Injection 15 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass Water for Injection 15 mg/ml 20-25°C Light
12 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 15 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 15 mg/ml 20-25°C Light
12 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.6 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.6 mg/ml 20-25°C Light
12 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 8 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 8 mg/ml 20-25°C Light
12 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0.6 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0.6 mg/ml 20-25°C Light
12 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 8 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 8 mg/ml 20-25°C Light
12 Hour

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