Bibliographie - 3705 - Stabilis 4.0

Last update :
03/05/2024

References 3705

Type :

Journal

Web link :

http://ejhp.bmj.com/content/21/3/161.abstract

Research teams :

Kiel - Christian-Albrechts- University Kiel, Pharmaceutical Institute

Authors :

Knudsen L, Eisend S, Haake N, Kunze T.

Title :

Physicochemical compatibility of commonly used analgesics and sedatives in the intensive care medicine.

Reference :

EJHP ;21:161-166 2014

Level of Evidence :

Physical stability :

Chemical stability :

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Stability defined as 90% of the initial concentration

Other methods :

Comments :

Stability indicating capability inadequately assessed

Repeatability / reproducibility / standard range: results not provided or results outside specified values

Unencrypted results (eg graphic)

Degradation products not observed in real conditions

List of drugs

Clonidine hydrochloride

0.015 mg/ml	+ Ketamine hydrochloride	25 mg/ml	+
0.015 mg/ml	+ Lormetazepam	0.12 mg/ml	+
0.015 mg/ml	+ Midazolam hydrochloride	3.6 mg/ml	+
0.015 mg/ml	+ Piritramide	1 mg/ml	+
0.015 mg/ml	+ Sodium oxybate	200 mg/ml	+
0.015 mg/ml	+ Sufentanil citrate	0.03 mg/ml	+

Ketamine hydrochloride

25 mg/ml	+ Clonidine hydrochloride	0.015 mg/ml	+
25 mg/ml	+ Lormetazepam	0.12 mg/ml	+
25 mg/ml	+ Midazolam hydrochloride	3.6 mg/ml	+
25 mg/ml	+ Piritramide	1 mg/ml	+
25 mg/ml	+ Sodium oxybate	200 mg/ml	+
25 mg/ml	+ Sufentanil citrate	0.03 mg/ml	+

Lormetazepam

0.12 mg/ml	+ Clonidine hydrochloride	0.015 mg/ml	+
0.12 mg/ml	+ Ketamine hydrochloride	25 mg/ml	+
0.12 mg/ml	+ Midazolam hydrochloride	3.6 mg/ml	+
0.12 mg/ml	+ Piritramide	1 mg/ml	+
0.12 mg/ml	+ Sodium oxybate	200 mg/ml	+
0.12 mg/ml	+ Sufentanil citrate	0.03 mg/ml	+

Midazolam hydrochloride

3.6 mg/ml	+ Clonidine hydrochloride	0.015 mg/ml	+
3.6 mg/ml	+ Ketamine hydrochloride	25 mg/ml	+
3.6 mg/ml	+ Lormetazepam	0.12 mg/ml	+
3.6 mg/ml	+ Piritramide	1 mg/ml	+
3,6 mg/ml	+ Sodium oxybate	200 mg/ml	+
3.6 mg/ml	+ Sufentanil citrate	0.03 mg/ml	+

Piritramide

1 mg/ml	+ Clonidine hydrochloride	0.015 mg/ml	+
1 mg/ml	+ Ketamine hydrochloride	25 mg/ml	+
1 mg/ml	+ Lormetazepam	0.12 mg/ml	+
1 mg/ml	+ Midazolam hydrochloride	3.6 mg/ml	+
1 mg/ml	+ Sodium oxybate	200 mg/ml	+
1 mg/ml	+ Sufentanil citrate	0.03 mg/ml	+

Sodium oxybate

200 mg/ml	+ Clonidine hydrochloride	0.015 mg/ml	+
200 mg/ml	+ Ketamine hydrochloride	25 mg/ml	+
200 mg/ml	+ Lormetazepam	0.12 mg/ml	+
200 mg/ml	+ Midazolam hydrochloride	3,6 mg/ml	+
200 mg/ml	+ Piritramide	1 mg/ml	+
200 mg/ml	+ Sufentanil citrate	0.03 mg/ml	+

Sufentanil citrate

0.03 mg/ml	+ Clonidine hydrochloride	0.015 mg/ml	+
0.03 mg/ml	+ Ketamine hydrochloride	25 mg/ml	+
0.03 mg/ml	+ Lormetazepam	0.12 mg/ml	+
0.03 mg/ml	+ Midazolam hydrochloride	3.6 mg/ml	+
0.03 mg/ml	+ Piritramide	1 mg/ml	+
0.03 mg/ml	+ Sodium oxybate	200 mg/ml	+

25°C

Clonidine hydrochloride	0,015 mg/ml
Midazolam hydrochloride	3,6 mg/ml
Sufentanil citrate	0,03 mg/ml

25°C

Clonidine hydrochloride	0,015 mg/ml
Lormetazepam	0,12 mg/ml

25°C

Clonidine hydrochloride	0,015 mg/ml
Ketamine hydrochloride	25 mg/ml

25°C

Clonidine hydrochloride	0,015 mg/ml
Midazolam hydrochloride	3,6 mg/ml

25°C

Clonidine hydrochloride	0,015 mg/ml
Piritramide	1 mg/ml

25°C

Ketamine hydrochloride	25 mg/ml
Lormetazepam	0,12 mg/ml

25°C

Ketamine hydrochloride	25 mg/ml
Midazolam hydrochloride	3,6 mg/ml

25°C

Lormetazepam	0,12 mg/ml
Piritramide	1 mg/ml

25°C

Lormetazepam	0,12 mg/ml
Sufentanil citrate	0,03 mg/ml

25°C

Midazolam hydrochloride	3,6 mg/ml
Sufentanil citrate	0,03 mg/ml

25°C

Clonidine hydrochloride	0,015 mg/ml
Piritramide	1 mg/ml
Midazolam hydrochloride	3,6 mg/ml
Ketamine hydrochloride	25 mg/ml
Lormetazepam	0,12 mg/ml
Sufentanil citrate	0,03 mg/ml

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