Last update :
18/04/2024
References   References 3665  
Type : Journal
Web link : http://www.ajhp.org/content/71/11/956.abstract

Research teams : Grenade - Faculty of Science, Department of Analytical Chemistry
Authors : Ortega R, Salmer?n-Garc?a A, Cabeza J, Capit?n-Vallvey L.F, Navas N.
Title : Stability of daptomycin 5 mg/mL and heparin sodium 100 units/mL combined in lactated Ringer’s injection and stored in polypropylene syringes at 4 and -20°C.
Reference : Am J Health-Syst Pharm ; 71:956-959 2014

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Degradation products not observed in real conditions

List of drugs
InjectionDaptomycin Antibiotic
InjectionHeparin sodium Anticoagulant
Stability of mixtures
Polypropylen Syringe Ringer’s lactate solution -20°C Protect from light
Injection Heparin sodium 100 UI/ml
Injection Daptomycin 5 mg/ml
14 Day
Polypropylen Syringe Ringer’s lactate solution 4°C Not specified
Injection Heparin sodium 100 UI/ml
Injection Daptomycin 5 mg/ml
14 Day

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