Last update :
28/04/2024
References   References 3291  
Type : Journal

Research teams : Bydgoszcz - Nicolaus Copernicus University Collegium Medicum
Authors : Kodym A, Bilski P, Domanska A, Lukasz Helminiak, Jablonska M, Jachymska A.
Title : Physical and chemical properties and stability of sodium cefazolin in buffered eye drops determined with HPLC method.
Reference : Acta Pol Pharm ; 69, 1: 95-105. 2012

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
Eye-dropsCefazolin sodium Antibiotic
Stability in solutions Not specified Medicine bottle for injection 500 mg
Biofazolin®
Citrate buffer pH 6.27 - 161 mOsmol/L 9.5 g
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 500 mg
Biofazolin®
Citrate buffer pH 6.27 - 161 mOsmol/L 9.21 g
Borate Phenylmercuric 0.04% 250 mg
Texte introuvable (10553, ) 40 mg
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 500 mg
Biofazolin®
Citrate buffer pH 6.22 - 308 mOsmol/L 4.605 g
Polyvinyl alcohol ŋ = 42.3 mPas pH 4.48 4.605 g
Borate Phenylmercuric 0.04% 250 mg
Texte introuvable (10553, ) 40 mg
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 500 mg
Biofazolin®
Citrate buffer pH 6.22 - 308 mOsmol/L 4.750 g
Polyvinyl alcohol ŋ = 42.3 mPas pH 4.48 4.750 g
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 100 mg
Biofazolin®
Citrate buffer pH 6.22 - 308 mOsmol/L 9.9 g
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 100 mg
Biofazolin®
Citrate buffer pH 6.22 - 308 mOsmol/L 9.610 g
Borate Phenylmercuric 0.04% 250 mg
Texte introuvable (10553, ) 40 mg
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 100 mg
Biofazolin®
Citrate buffer pH 6.11 - 581 mOsmol/L 4.950 g
Polyvinyl alcohol ŋ = 42.3 mPas pH 4.48 4.950 g
4°C Protect from light
30 Day
Stability in solutions Not specified Medicine bottle for injection 100 mg
Biofazolin®
Citrate buffer pH 6.11 - 581 mOsmol/L 4.805 g
Polyvinyl alcohol ŋ = 42.3 mPas pH 4.48 4.805 g
Borate Phenylmercuric 0.04% 250 mg
Texte introuvable (10553, ) 40 mg
4°C Protect from light
30 Day

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