Last update :
19/11/2024
References   References 3290  
Type : Journal

Research teams : Bydgoszcz - Nicolaus Copernicus University Collegium Medicum
Authors : Kodym A, Wisniewski A, Kniola D, Olejniczak M.
Title : Stability of cefuroxime in 1% and 5% buffered eye drops determined with HPLC method.
Reference : Acta Pol Pharm ; 68, 4: 555-564. 2011

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
Eye-dropsCefuroxime sodium Antibiotic
Factors which affect stability Temperature 20°C Induces Reduced stability
Stability in solutions Not specified Medicine bottle for injection 1 g
® = Biouroksym®
Water for injection 99 g
4°C Protect from light
27 Day
Stability in solutions Not specified Medicine bottle for injection 1 g
® = Biouroksym®
Citrate buffer pH 6.25 - 302 mOsmol/L 99 g
4°C Protect from light
15 Day
Stability in solutions Not specified Medicine bottle for injection 1 g
® = Biouroksym®
Borate Phenylmercuric 0,04% 2,5 g
ßphenylethylalcool 0.4 g
Citrate buffer pH 6.25 - 302 mOsmol/L 96.1 g
4°C Protect from light
15 Day
Stability in solutions Not specified Medicine bottle for injection 1 g
® = Biouroksym®
polyvinyl alcohol ŋ = 42 mPas pH 5.75 49.5 g
Borate Phenylmercuric 0.04% 2.5g
ßphenylethylalcool 0.4 g
Citrate buffer pH 6.05 - 581 mOsmol/L 49.5 g
4°C Protect from light
18 Day
Stability in solutions Not specified Medicine bottle for injection 1 g
® = Biouroksym®
polyvinyl alcohol ŋ = 42 mPas pH 5.75 49.5 g
Citrate buffer pH 6.05 - 581 mOsmol/L 49.5 g
4°C Protect from light
18 Day
Stability in solutions Not specified Medicine bottle for injection 5 g
® = Biouroksym®
Water for injection 95 g
4°C Protect from light
27 Day
Stability in solutions Not specified Medicine bottle for injection 5 g
® = Biouroksym®
Citrate buffer pH 6.28- 160 mOsmol/L 95 g
4°C Protect from light
15 Day
Stability in solutions Not specified Medicine bottle for injection 5 g
® = Biouroksym®
Borate Phenylmercuric 0,04% 2,5 g
ßphenylethylalcool 0.4 g
Citrate buffer pH 6.28- 160 mOsmol/L 92.1 g
4°C Protect from light
15 Day
Stability in solutions Not specified Medicine bottle for injection 5 g
® = Biouroksym®
polyvinyl alcohol ŋ = 42 mPas pH 5.75 47.5 g
Citrate buffer pH 6.25 - 302 mOsmol/L 47.5 g
4°C Protect from light
27 Day
Stability in solutions Not specified Medicine bottle for injection 5 g
® = Biouroksym®
polyvinyl alcohol ŋ = 42 mPas pH 5.75 46.05 g
Borate Phenylmercuric 0.04% 2.5g
ßphenylethylalcool 0.4 g
Citrate buffer pH 6.25 - 302 mOsmol/L 46.05 g
4°C Protect from light
30 Day

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