Bibliographie - 3159 - Stabilis 4.0

Last update :
28/04/2024

References 3159

Type :

Journal

Web link :

https://doi.org/10.1016/S1875-4597(10)60042-2

Research teams :

Taipei - National Taiwan University Hospital, Department of Anesthesiology

Authors :

Lin, T.-F., Lin, F.-S., Chou, W.-H., Yeh, Y.-C., Lin, C.-P., Fan, S.-Z., Sun, W.-Z.

Title :

Compatibility and stability of binary mixtures of ketorolac tromethamine and tramadol hydrochloride injection concentrate and diluted infusion solution.

Reference :

Acta Anaesthesiol Taiwan ; 48, 3 : 117-121. 2010

Level of Evidence :

Physical stability :

Chemical stability :

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Stability defined as 95% of the initial concentration

Other methods :

Comments :

Stability indicating capability inadequately assessed

Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs

Ketorolac tromethamine

	2 mg/ml	+ Tramadol hydrochloride	20 mg/ml	+
	10 mg/ml	+ Tramadol hydrochloride	33.3 mg/ml	+

Tramadol hydrochloride

	20 mg/ml	+ Ketorolac tromethamine	2 mg/ml	+
	33.3 mg/ml	+ Ketorolac tromethamine	10 mg/ml	+

25°C

Ketorolac tromethamine	2 mg/ml
Tramadol hydrochloride	20 mg/ml

25°C

Ketorolac tromethamine	10 mg/ml
Tramadol hydrochloride	33,3 mg/ml

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