Last update :
19/11/2024
References   References 3076  
Type : Journal
Web link : https://www.em-consulte.com/article/231296/article/effect-of-freezing-long-term-storage-and-microwave

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : François JH, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
Title : Effect of freezing, long-term storage and microwave thawing on the stability of a mixture of diclofenac and sodium bicarbonate in glucose 5% polyolefin bags.
Reference : Ann Pharm Fr ; 67: 427-432. 2009

Level of Evidence : 
Level of evidence C+
Physical stability : 
Microscopic examination Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionDiclofenac Anti-inflammatory
injectionSodium bicarbonate Electrolyte
Stability of mixtures
Polyethylene Glucose 5% - 20°C Protect from light
injection Sodium bicarbonate 0,42 mg/ml
injection Diclofenac 0,75 mg/ml
60 Day
Polyethylene Glucose 5% 2-8°C Protect from light
injection Sodium bicarbonate 0,42 mg/ml
injection Diclofenac 0,75 mg/ml
30 Day

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