Last update :
28/04/2024
References   References 2878  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/824

Research teams : Ottawa - The Ottawa Hospital, department of Pharmacy
Authors : Pascuet E, Donnelly RF, Garceau D, Vaillancourt R.
Title : Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes.
Reference : Can J Hosp Pharm ; 62, 5: 375-380. 2009

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 9 µg/ml + InjectionLidocaine hydrochloride 9 & 18 mg/ml + NaHCO3
InjectionLidocaine hydrochloride Local anesthetic
Compatible 9 & 18 mg/ml + InjectionEpinephrine hydrochloride 9 µg/ml + NaHCO3
InjectionSodium bicarbonate Electrolyte
Stability of mixtures
Polypropylene None 4-7°C Protect from light
Injection Lidocaine hydrochloride 9 mg/ml
Injection Sodium bicarbonate 7,8 mg/ml
Injection Epinephrine hydrochloride 9 µg/ml
7 Day
Polypropylene None 4-7°C Protect from light
Injection Lidocaine hydrochloride 18 mg/ml
Injection Sodium bicarbonate 7,8 mg/ml
Injection Epinephrine hydrochloride 9 µg/ml
7 Day
Polypropylene None 4-7°C Protect from light
Injection Sodium bicarbonate 7,8 mg/ml
Injection Lidocaine hydrochloride 9 mg/ml
28 Day
Polypropylene None 4-7°C Protect from light
Injection Lidocaine hydrochloride 18 mg/ml
Injection Sodium bicarbonate 7,8 mg/ml
28 Day

  Mentions Légales