Last update :
19/11/2024
References   References 2878  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/824

Research teams : Ottawa - The Ottawa Hospital, department of Pharmacy
Authors : Pascuet E, Donnelly RF, Garceau D, Vaillancourt R.
Title : Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes.
Reference : Can J Hosp Pharm ; 62, 5: 375-380. 2009

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 9 µg/ml + injectionLidocaine hydrochloride 9 & 18 mg/ml + NaHCO3
injectionLidocaine hydrochloride Local anesthetic
Compatible 9 & 18 mg/ml + injectionEpinephrine hydrochloride 9 µg/ml + NaHCO3
injectionSodium bicarbonate Electrolyte
Stability of mixtures
Polypropylene None 4-7°C Protect from light
injection Lidocaine hydrochloride 9 mg/ml
injection Sodium bicarbonate 7,8 mg/ml
injection Epinephrine hydrochloride 9 µg/ml
7 Day
Polypropylene None 4-7°C Protect from light
injection Lidocaine hydrochloride 18 mg/ml
injection Sodium bicarbonate 7,8 mg/ml
injection Epinephrine hydrochloride 9 µg/ml
7 Day
Polypropylene None 4-7°C Protect from light
injection Sodium bicarbonate 7,8 mg/ml
injection Lidocaine hydrochloride 9 mg/ml
28 Day
Polypropylene None 4-7°C Protect from light
injection Lidocaine hydrochloride 18 mg/ml
injection Sodium bicarbonate 7,8 mg/ml
28 Day

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