Last update :
19/11/2024
References   References 2350  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=984

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Roy J.J, Hildgen P.
Title : Stability of morphine-ketamine in 0.9% sodium chloride injection packaged in syringes, plastic bags and MEDICATION CASSETTE Reservoirs.
Reference : Int J Pharm Compound ; 4, 3: 225-228. 2000

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection

List of drugs
injectionKetamine hydrochloride General anesthetic
injectionMorphine sulfate Analgesic
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 25°C Not specified
injection Ketamine hydrochloride 1 & 25 mg/ml
injection Morphine sulfate 1 & 25 mg/ml
6 Day
Polypropylene Sodium chloride 0,9% 25°C Not specified
injection Morphine sulfate 1 >> 25 mg/ml
injection Ketamine hydrochloride 1 >> 25 mg/ml
6 Day

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