Last update :
19/11/2024
References   References 2322  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/114

Research teams : Ottawa - The Ottawa Hospital, department of Pharmacy
Authors : Donnelly R.F.
Title : Physical Compatibility and Chemical Stability of Ketamine–Morphine Mixtures in Polypropylene Syringes.
Reference : Can J Hosp Pharm ; 62, 1 2009

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionKetamine hydrochloride General anesthetic
Compatible 2 mg/ml + injectionMorphine sulfate 2 >> 10 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 2 >> 10 mg/ml + injectionKetamine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 23°C Light
injection Ketamine hydrochloride 2 mg/ml
injection Morphine sulfate 2 >> 10 mg/ml
91 Day
Polypropylene Sodium chloride 0,9% 5°C Protect from light
injection Ketamine hydrochloride 2 mg/ml
injection Morphine sulfate 2 >> 10 mg/ml
91 Day

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