Last update :
19/11/2024
References   References 2211  
Type : Journal
Web link : https://doi.org/10.1111/j.1365-2710.2007.00839.x

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Negro S, Salama A, S?nchez Y, AzuaraM.L, Barcia B.
Title : Compatibility and stability of tramadol and dexamethasone in solution and its use in terminally ill patients.
Reference : J Clin Pharm Ther ; 32: 441-444. 2007

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
Other methods : 
Water loss by evaporation 
Comments : 
Method not shown but the article refers to a validated method

List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.33>>3.33 mg/ml + injectionTramadol hydrochloride 8.33>>33.33 mg/ml + Sodium chloride 0,9%
injectionTramadol hydrochloride Analgesic
Factors which affect stability Storage Light Induces Degradation
Compatible 8.33>>33.33 mg/ml + injectionDexamethasone sodium phosphate 0.33>>3.33 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
injection Tramadol hydrochloride 8.33>>33.33 mg/ml
injection Dexamethasone sodium phosphate 0.33>>3.33 mg/ml
5 Day

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