Last update :
28/04/2024
References   References 2166  
Type : Journal

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Nassr S, Dubuc MC, Lavoie P, Brazier JL.
Title : HPLC-DAD methods for studying the stability of solutions containing hydromorphone, ketorolac, haloperidol, midazolam, famotidine, metoclopramide, dimenhydrinate and scopolamine.
Reference : J Liquid Chrom Rel Technol ; 26, 17: 2909-2929. 2003

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionDimenhydrinate Antihistamine (H1)
InjectionFamotidine Antihistamine (H2)
InjectionHaloperidol lactate Neuroleptic
InjectionHydromorphone hydrochloride Analgesic
SuppositoryKetoprofene Anti-inflammatory
InjectionKetorolac tromethamine Anti-inflammatory
InjectionMetoclopramide hydrochloride Antiemetic
InjectionMidazolam hydrochloride Anxiolytic
InjectionScopolamine hydrobromide Antimuscarinic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
Injection Scopolamine hydrobromide 0,04 mg/ml
Injection Famotidine 0,4 mg/ml
Injection Haloperidol lactate 0,5 mg/ml
Injection Dimenhydrinate 5 mg/ml
Injection Hydromorphone hydrochloride 10 mg/ml
12 Hour
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
Injection Famotidine 0,4 mg/ml
Injection Midazolam hydrochloride 1 mg/ml
Injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
Injection Haloperidol lactate 0,5 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
Injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
Injection Famotidine 0,4 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
Suppository Ketoprofene   
Injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Scopolamine hydrobromide 0,04 mg/ml
Injection Famotidine 0,4 mg/ml
Injection Haloperidol lactate 0,5 mg/ml
Injection Dimenhydrinate 5 mg/ml
Injection Hydromorphone hydrochloride 10 mg/ml
12 Hour
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Famotidine 0,4 mg/ml
Injection Midazolam hydrochloride 1 mg/ml
Injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Famotidine 0,4 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
Injection Ketorolac tromethamine 1,5 mg/ml
Injection Hydromorphone hydrochloride 10 mg/ml
96 Hour

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