Last update :
18/07/2024
References   References 2166  
Type : Journal

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Nassr S, Dubuc MC, Lavoie P, Brazier JL.
Title : HPLC-DAD methods for studying the stability of solutions containing hydromorphone, ketorolac, haloperidol, midazolam, famotidine, metoclopramide, dimenhydrinate and scopolamine.
Reference : J Liquid Chrom Rel Technol ; 26, 17: 2909-2929. 2003

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionDimenhydrinate Antihistamine (H1)
injectionFamotidine Antihistamine (H2)
injectionHaloperidol lactate Neuroleptic
injectionHydromorphone hydrochloride Analgesic
suppositoryKetoprofene Anti-inflammatory
injectionKetorolac tromethamine Anti-inflammatory
injectionMetoclopramide hydrochloride Antiemetic
injectionMidazolam hydrochloride Anxiolytic
injectionScopolamine hydrobromide Antimuscarinic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
injection Scopolamine hydrobromide 0,04 mg/ml
injection Famotidine 0,4 mg/ml
injection Haloperidol lactate 0,5 mg/ml
injection Dimenhydrinate 5 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
12 Hour
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
injection Famotidine 0,4 mg/ml
injection Midazolam hydrochloride 1 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
injection Haloperidol lactate 0,5 mg/ml
injection Metoclopramide hydrochloride 0,5 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 25°C Not specified
injection Famotidine 0,4 mg/ml
injection Metoclopramide hydrochloride 0,5 mg/ml
suppository Ketoprofene   
injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
injection Scopolamine hydrobromide 0,04 mg/ml
injection Famotidine 0,4 mg/ml
injection Haloperidol lactate 0,5 mg/ml
injection Dimenhydrinate 5 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
12 Hour
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
injection Famotidine 0,4 mg/ml
injection Midazolam hydrochloride 1 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
96 Hour
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
injection Famotidine 0,4 mg/ml
injection Metoclopramide hydrochloride 0,5 mg/ml
injection Ketorolac tromethamine 1,5 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
96 Hour

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