Last update :
19/11/2024
References   References 2036  
Type : Journal
Web link : https://doi.org/10.1345/aph.1G161

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Trissel LA.
Title : Physical and chemical stability of pemetrexed solutions in plastic syringes.
Reference : Ann Pharmacotherapy ; 39, 12: 2026-2028. 2005

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
injectionPemetrexed disodium Anticancer drug
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 25 mg/ml 23°C With or without light
2 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 25 mg/ml 4°C Protect from light
31 Day

  Mentions Légales