Last update :
19/11/2024
References   References 1955  
Type : Journal
Web link : https://doi.org/10.1345/aph.1E408

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Zhang Y.
Title : Palonosetron HCl compatibility and stability with doxorubicin HCl and epirubicin HCl during simulated Y-site administration.
Reference : Ann Pharmacotherapy ; 39: 280-283. 2005

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionDoxorubicin hydrochloride Anticancer drug
Compatible 1 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionEpirubicin hydrochloride Anticancer drug
Compatible 0,5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionDoxorubicin hydrochloride 1 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionEpirubicin hydrochloride 0,5 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 23°C Not specified
injection Palonosetron hydrochloride 25 µg/ml
injection Doxorubicin hydrochloride 0,1 mg/ml
4 Hour
Glass Glucose 5% 23°C Not specified
injection Palonosetron hydrochloride 26 µg/ml
injection Epirubicin hydrochloride 0,26 mg/ml
4 Hour

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