Last update :
19/11/2024
References   References 1948  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S0885392404003963

Research teams : Oklahoma City - Analytical Research Laboratories (T.C.K.)
Authors : Classen AM, Wimbish GH, Kupiec TC.
Title : Stability of admixtures containing morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride in an implantable infusion system.
Reference : J Pain Symptom Manage ; 28, 6: 603-611. 2004

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement PH measurement 
Comments : 

List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionClonidine hydrochloride Antihypertensive
injectionMorphine sulfate Analgesic
Stability of mixtures
Glass None 37°C Protect from light
injection Morphine sulfate 50 mg/ml
injection Clonidine hydrochloride 2 mg/ml
injection Bupivacaine hydrochloride 25 mg/ml
90 Day
Glass None 4°C Protect from light
injection Morphine sulfate 50 mg/ml
injection Clonidine hydrochloride 2 mg/ml
injection Bupivacaine hydrochloride 25 mg/ml
90 Day

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