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18/07/2024
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References   References 1940  
Type : Journal
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA.
Title : Stability of palonosetron hydrochloride with paclitaxel and docetaxel during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 61: 1596-1598. 2004
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionDocetaxel Anticancer drug
Compatible 0,8 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPaclitaxel Anticancer drug
Compatible 1,2 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionDocetaxel 0,8 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionPaclitaxel 1,2 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 26,6 µg/ml
injection Paclitaxel 0,62 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 26,6 µg/ml
injection Docetaxel 0,41 mg/ml
4 Hour
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