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References   References 1906  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/61/1/38
Research teams : West Point - Merck and Co
Authors : McQuade MS, Van Nostrand V, Shariter J, Kanike JD, Forsyth RJ.
Title : Stability and compatibility of reconstituted ertapenem with commonly used iv infusion and coinfusion solutions.
Reference : Am J Health-Syst Pharm ; 61: 38-45. 2004
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products identified
List of drugs
injectionErtapenem Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Degradation
Factors which affect stability Temperature Increase Induces Reduced concentration
Factors which affect stability Temperature -20°C Induces Degradation
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 10 & 20 mg/ml 25°C Not specified
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 10 & 20 mg/ml 4°C Not specified
5 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 10 & 20 mg/ml 4°C Not specified
3 Day
Compatible 10 & 20 mg/ml + injectionHeparin sodium 50 & 100 UI/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionHetastarch 60 mg/ml + Sodium chloride 0,9%
Incompatible + Glucose 5%
Incompatible 10 & 20 mg/ml + injectionMannitol 100 & 200 mg/ml + None
Incompatible 10 & 20 mg/ml + injectionSodium bicarbonate + None
Incompatible 10 & 20 mg/ml + injectionSodium bicarbonate + NaHCO3
injectionHeparin sodium Anticoagulant
Compatible 50 & 100 UI/ml + injectionErtapenem 10 & 20 mg/ml + Sodium chloride 0,9%
injectionHetastarch Various
Compatible 60 mg/ml + injectionErtapenem 20 mg/ml + Sodium chloride 0,9%
injectionMannitol Various
Incompatible 100 & 200 mg/ml + injectionErtapenem 10 & 20 mg/ml + None
Compatible 20 mg/ml + injectionPotassium chloride 10000 & 40000 mEq/l + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 10000 & 40000 mEq/l + injectionMannitol 20 mg/ml + Sodium chloride 0,9%
injectionSodium bicarbonate Electrolyte
Incompatible + injectionErtapenem 10 & 20 mg/ml + None
Incompatible + injectionErtapenem 10 & 20 mg/ml + NaHCO3
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