Bibliographie - 1904 - Stabilis 4.0

Last update :
19/11/2024

References

References 1904

Type :

Journal

Web link :

http://www.ajhp.org/cgi/content/abstract/60/9/916

Research teams :

Research Triangle Park - United Therapeutics corporation

Authors :

Phares KR, Weiser WE, Miller SP, Myers MA, Wade M.

Title :

Stability and preservative effectiveness of treprostinil sodium after dilution in common intravenous diluents.

Reference :

Am J Health-Syst Pharm ; 60: 916-922. 2003

Level of Evidence :

Level of evidence A

AideBibliographie

Physical stability :

Visual examination

Chemical stability :

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Stability defined as 95% of the initial concentration

Other methods :

PH measurement

Comments :

List of drugs

injection

Treprostinil

Vasodilator

Stability in solutions

Polyvinyl chloride

Water for Injection

0,004 & 0,13 mg/ml

40°C

Not specified

48

Hour

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

0,13 mg/ml

40°C

Not specified

48

Hour

Stability in solutions

Polyvinyl chloride

Sodium chloride 0,9%

0,004 mg/ml

40°C

Not specified

48

Hour

Stability in solutions

Polyvinyl chloride

Glucose 5%

0,02 mg/ml

40°C

Not specified

48

Hour

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