Last update :
06/05/2024
References   References 1902  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/358

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Wyllie A, Law S.
Title : Physical compatibility of pantoprazole with selected medications during simulated Y-site administration.
Reference : Can J Hosp Pharm ; 57, 2: 90-96. 2004

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAmpicillin sodium Antibiotic
Compatible 10 >> 40 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Compatible 20 >> 40 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionCeftriaxone disodium Antibiotic
Compatible 20 >> 40 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionDimenhydrinate Antihistamine (H1)
Compatible 0.5 >> 1 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 1 >> 4 mg/ml + InjectionPantoprazole sodium 0,16 >> 0,8 mg/ml + Sodium chloride 0,9%
Compatible < 4 mg/ml + InjectionPantoprazole sodium < 0.05 mg/ml + Sodium chloride 0,9%
InjectionDopamine hydrochloride Cardiotonic
Compatible 0.8 >> 3.2 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 16 >> 32 µg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionEsmolol hydrochloride Beta-blocker
Incompatible > 2 mg/ml + InjectionPantoprazole sodium > 0.12 mg/ml + Sodium chloride 0,9%
Incompatible < 2 mg/ml + InjectionPantoprazole sodium < 0.12 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Compatible 1 >> 2 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionInsulin Glucose-lowering
Compatible 5 >> 50 UI/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionMidazolam hydrochloride Anxiolytic
Incompatible > 0.1 mg/ml + InjectionPantoprazole sodium > 0.01 mg/ml + Sodium chloride 0,9%
Compatible < 0.1 mg/ml + InjectionPantoprazole sodium < 0.01 mg/ml + Sodium chloride 0,9%
InjectionNitroglycerin Vasodilator
Compatible 0.1 >> 0.4 mg/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionNorepinephrine bitartrate Sympathomimetic
Incompatible > 0.064 mg/ml + InjectionPantoprazole sodium > 0.8 mg/ml + Sodium chloride 0,9%
Compatible < 0.013 mg/ml + InjectionPantoprazole sodium < 0.8 mg/ml + Sodium chloride 0,9%
Compatible < 0.064 mg/ml + InjectionPantoprazole sodium < 0.1 mg/ml + Sodium chloride 0,9%
InjectionOctreotide acetate Various
Compatible < 0.0015 mg/ml + InjectionPantoprazole sodium < 0.8 mg/ml + Sodium chloride 0,9%
Incompatible > 0.004 mg/ml + InjectionPantoprazole sodium > 0.5 mg/ml + Sodium chloride 0,9%
Compatible < 0.004 mg/ml + InjectionPantoprazole sodium > 0.5 mg/ml + Sodium chloride 0,9%
InjectionPantoprazole sodium Proton pump inhibitor
Compatible 0.16 >> 0.8 mg/ml + InjectionAmpicillin sodium 10 >> 40 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionCefazolin sodium 20 >> 40 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionCeftriaxone disodium 20 >> 40 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionDimenhydrinate 0.5 >> 1 mg/ml + Sodium chloride 0,9%
Incompatible 0,16 >> 0,8 mg/ml + InjectionDobutamine hydrochloride 1 >> 4 mg/ml + Sodium chloride 0,9%
Compatible < 0.05 mg/ml + InjectionDobutamine hydrochloride < 4 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionDopamine hydrochloride 0.8 >> 3.2 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionEpinephrine hydrochloride 16 >> 32 µg/ml + Sodium chloride 0,9%
Incompatible > 0.12 mg/ml + InjectionEsmolol hydrochloride > 2 mg/ml + Sodium chloride 0,9%
Incompatible < 0.12 mg/ml + InjectionEsmolol hydrochloride < 2 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionFurosemide 1 >> 2 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionInsulin 5 >> 50 UI/ml + Sodium chloride 0,9%
Incompatible > 0.01 mg/ml + InjectionMidazolam hydrochloride > 0.1 mg/ml + Sodium chloride 0,9%
Compatible < 0.01 mg/ml + InjectionMidazolam hydrochloride < 0.1 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionNitroglycerin 0.1 >> 0.4 mg/ml + Sodium chloride 0,9%
Incompatible > 0.8 mg/ml + InjectionNorepinephrine bitartrate > 0.064 mg/ml + Sodium chloride 0,9%
Compatible < 0.8 mg/ml + InjectionNorepinephrine bitartrate < 0.013 mg/ml + Sodium chloride 0,9%
Compatible < 0.1 mg/ml + InjectionNorepinephrine bitartrate < 0.064 mg/ml + Sodium chloride 0,9%
Compatible < 0.8 mg/ml + InjectionOctreotide acetate < 0.0015 mg/ml + Sodium chloride 0,9%
Incompatible > 0.5 mg/ml + InjectionOctreotide acetate > 0.004 mg/ml + Sodium chloride 0,9%
Compatible > 0.5 mg/ml + InjectionOctreotide acetate < 0.004 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionPotassium chloride 20 >> 4000 mEq/l + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + InjectionVasopressin 0.4 >> 1 UI/ml + Sodium chloride 0,9%
InjectionPotassium chloride Electrolyte
Compatible 20 >> 4000 mEq/l + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
InjectionVasopressin Hormone
Compatible 0.4 >> 1 UI/ml + InjectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%

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