Last update :
03/05/2024
References   References 1892  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=1747

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Lebrun J, Hecq JD, Vanbeckbergen D, Jalart J, Galanti LM.
Title : Effect of freezing, long-term storage and microwave thawing on the stability of tramadol in 5% dextrose infusion in polyvinyl chloride bags.
Reference : Int J Pharm Compound ; 8, 2: 156-159. 2004

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionTramadol hydrochloride Analgesic
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml -20°C Protect from light
120 Day
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml 4°C Not specified
60 Day

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