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References   References 1869  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S0885392403000411
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Hildebrand KR, Elsberry DD, Hassenbusch SJ.
Title : Stability and compatibility of morphine-clonidine admixtures in an implantable infusion system.
Reference : J Pain Symptom Manage ; 25, 5: 464-471. 2003
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionClonidine hydrochloride Antihypertensive
Compatible 0,05 & 1,84 mg/ml + InjectionMorphine sulfate 2 & 20 mg/ml + Sodium chloride 0,9%
InjectionMorphine sulfate Analgesic
Compatible 2 & 20 mg/ml + InjectionClonidine hydrochloride 0,05 & 1,84 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Not specified None 37°C Not specified
Injection Morphine sulfate 20 mg/ml
Injection Clonidine hydrochloride 0,05 mg/ml
90 Day
Not specified None 37°C Not specified
Injection Morphine sulfate 2 mg/ml
Injection Clonidine hydrochloride 1,84 mg/ml
90 Day
  Mentions Légales