Last update :
19/11/2024
References   References 1707  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=350

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Xu QA, Pham L.
Title : Physical and chemical stability of low and high concentrations of morphine sulfate with bupivacaine hydrochloride packaged in plastic syringes.
Reference : Int J Pharm Compound ; 6: 70-73. 2002

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionMorphine sulfate Analgesic
Stability of mixtures
Polypropylene Water for Injection 23°C Light
injection Morphine sulfate 50 mg/ml
injection Bupivacaine hydrochloride 25 mg/ml
60 Day
Polypropylene Water for Injection 37°C Protect from light
injection Morphine sulfate 50 mg/ml
injection Bupivacaine hydrochloride 25 mg/ml
48 Hour
Polypropylene Water for Injection 4°C Protect from light
injection Morphine sulfate 50 mg/ml
injection Bupivacaine hydrochloride 25 mg/ml
60 Day
Polypropylene Sodium chloride 0,9% 23°C Light
injection Morphine sulfate 5 mg/ml
injection Bupivacaine hydrochloride 2,5 mg/ml
60 Day
Polypropylene Sodium chloride 0,9% 37°C Protect from light
injection Morphine sulfate 5 mg/ml
injection Bupivacaine hydrochloride 2,5 mg/ml
48 Hour
Polypropylene Sodium chloride 0,9% 4°C Protect from light
injection Morphine sulfate 5 mg/ml
injection Bupivacaine hydrochloride 2,5 mg/ml
60 Day

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