Last update :
27/11/2024
References   References 1639  
Type : Journal

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Krämer I.
Title : Stability of meropenem in elastomeric portable infusion devices.
Reference : Eur Hosp Pharm ; 3: 168-171. 1997

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified

List of drugs
injectionMeropenem Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 10 mg/ml 24°C Protect from light
6 Hour
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
96 Hour
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 24°C Protect from light
24 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 10 mg/ml 2-8°C Protect from light
96 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 10 mg/ml 24°C Protect from light
6 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
96 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 5 mg/ml 24°C Protect from light
24 Hour

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