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References   References 1495  
Type : Journal
Research teams : Belfast - Belfast City Hospital, Department of Pharmacy
Authors : Nixon AR, O'Hare MCB, Chisakuta AM.
Title : The stability of morphine sulphate and metoclopramide hydrochloride in various delivery presentations.
Reference : Pharm J ; 254: 153-155. 1995
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Water loss by evaporation PH measurement 
Comments : 
List of drugs
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 0.5 mg/ml + InjectionMorphine sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + InjectionMetoclopramide hydrochloride 0.5 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass Sodium chloride 0,9% 22°C Protect from light
Injection Morphine sulfate 1 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
42 Day
Glass Sodium chloride 0,9% 4°C Protect from light
Injection Morphine sulfate 1 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
189 Day
Glass Glucose 5% 22°C Protect from light
Injection Morphine sulfate 1 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
14 Day
Glass Glucose 5% 4°C Protect from light
Injection Morphine sulfate 1 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
35 Day
Polyvinyl chloride Sodium chloride 0,9% 22°C Protect from light
Injection Morphine sulfate 1 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
42 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
Injection Morphine sulfate 1 mg/ml
Injection Metoclopramide hydrochloride 0,5 mg/ml
189 Day
Polypropylen Syringe Sodium chloride 0,9% 22°C Protect from light
Injection Metoclopramide hydrochloride 0,5 mg/ml
Injection Morphine sulfate 1 mg/ml
42 Day
Polypropylen Syringe Sodium chloride 0,9% 4°C Protect from light
Injection Metoclopramide hydrochloride 0,5 mg/ml
Injection Morphine sulfate 1 mg/ml
189 Day
  Mentions Légales