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References   References 1467  
Type : Journal
Research teams : Parkville - Monash University, Victorian College of Pharmacy
Authors : Sitaram BR, Tsui M, Rawicki HB, Lam S, Courage P, Sitaram M, Chapman CB.
Title : Stability and compatibility of baclofen and morphine admixtures for use in an implantable infusion pump.
Reference : Int J Pharm ; 118: 181-189. 1995
Level of Evidence : 
Level of evidence A+
Physical stability : 
Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionBaclofen Various
Compatible 0.2 & 0.8 mg/ml + injectionMorphine sulfate 1 & 1.5 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 1 & 1.5 mg/ml + injectionBaclofen 0.2 & 0.8 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 37°C Not specified
injection Baclofen 0,2 & 0,8 mg/ml
injection Morphine sulfate 1 & 1,5 mg/ml
30 Day
  Mentions Légales