Last update :
19/11/2024
References   References 119  
Type : Journal

Research teams : Omaha - University of Nebraska Medical center, College of pharmacy
Authors : Strong ML, Schaaf LJ, Pankaskie MC, Robinson DH.
Title : Shelf-lives and factors affecting the stability of morphine sulphate and meperidine (pethidine) hydrochloride in plastic syringes for use in patient-controlled analgesic devices.
Reference : J Clin Pharm Ther ; 19: 361-369. 1994

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionMorphine sulfate Analgesic
Factors which affect stability Storage Light Induces Degradation
injectionPethidine hydrochloride Analgesic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 10 mg/ml -20°C Protect from light
84 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 10 mg/ml 23°C Light
84 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
84 Day

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