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References   References 1026  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/56/9/875
Research teams : Philadelphia - Philadelphia College of Pharmacy and Science
Authors : Mayron D, Gennaro AR.
Title : Stability and compatibility of topotecan hydrochloride with selected drugs.
Reference : Am J Health-Syst Pharm ; 56: 875-881. 1999
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
List of drugs
InjectionCarboplatin Anticancer drug
Compatible 0.9 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 5.76 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCisplatin Anticancer drug
Compatible 0.168 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCyclophosphamide Anticancer drug
Compatible 20 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + InjectionTopotecan 0.056 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + InjectionTopotecan 0.056 mg/ml + Glucose 5%
InjectionDoxorubicin hydrochloride Anticancer drug
Compatible 2 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFluorouracil Anticancer drug
Incompatible 50 mg/ml + InjectionTopotecan 0.056 mg/ml + Sodium chloride 0,9%
Compatible 50 mg/ml + InjectionTopotecan 0.056 mg/ml + Glucose 5%
InjectionGranisetron hydrochloride Antiemetic
Compatible 0.02 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionIfosfamide Anticancer drug
Compatible 14.28 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 2.4 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 1.72 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMitomycin Anticancer drug
Incompatible 0.084 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.48 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPaclitaxel Anticancer drug
Compatible 0.54 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionProchlorperazine edysilate Neuroleptic
Compatible 0.192 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 47.6/1.6 mg/ml + InjectionTopotecan 0.056 mg/ml + Sodium chloride 0,9%
Incompatible 47.6/1.6 mg/ml + InjectionTopotecan 0.056 mg/ml + Glucose 5%
InjectionTopotecan Anticancer drug
Compatible 0.056 mg/ml + InjectionCarboplatin 0.9 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionCimetidine hydrochloride 5.76 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionCisplatin 0.168 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionCyclophosphamide 20 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.056 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + Sodium chloride 0,9%
Compatible 0.056 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + Glucose 5%
Compatible 0.056 mg/ml + InjectionDoxorubicin hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionEtoposide 0.4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.056 mg/ml + InjectionFluorouracil 50 mg/ml + Sodium chloride 0,9%
Compatible 0.056 mg/ml + InjectionFluorouracil 50 mg/ml + Glucose 5%
Compatible 0.056 mg/ml + InjectionGranisetron hydrochloride 0.02 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionIfosfamide 14.28 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionMethylprednisolone sodium succinate 2.4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionMetoclopramide hydrochloride 1.72 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.056 mg/ml + InjectionMitomycin 0.084 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionOndansetron hydrochloride 0.48 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionPaclitaxel 0.54 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionProchlorperazine edysilate 0.192 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + InjectionTicarcillin / clavulanic acid 47.6/1.6 mg/ml + Sodium chloride 0,9%
Incompatible 0.056 mg/ml + InjectionTicarcillin / clavulanic acid 47.6/1.6 mg/ml + Glucose 5%
Compatible 0.056 mg/ml + InjectionVincristine sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionVincristine sulfate Anticancer drug
Compatible 1 mg/ml + InjectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Carboplatin 0,45 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Cimetidine hydrochloride 2,88 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Cisplatin 0,084 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Cyclophosphamide 10 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Doxorubicin hydrochloride 1 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Etoposide 0,2 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Granisetron hydrochloride 0,01 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Ifosfamide 7,14 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Methylprednisolone sodium succinate 1,2 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Metoclopramide hydrochloride 0,86 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Ondansetron hydrochloride 0,24 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Paclitaxel 0,27 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Prochlorperazine edysilate 0,096 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
Injection Topotecan 0,028 mg/ml
Injection Vincristine sulfate 0,5 mg/ml
4 Hour
  Mentions Légales