Ultimele actualizari :
28/04/2024
Bibliografie   Bibliografie 1026  
Tip : Ziar
Internet legătură într- : http://www.ajhp.org/cgi/content/abstract/56/9/875

Echipe de cercetare : Philadelphie - Philadelphia College of Pharmacy and Science
Autor : Mayron D, Gennaro AR.
Titlu : Stability and compatibility of topotecan hydrochloride with selected drugs.
Référence : Am J Health-Syst Pharm ; 56: 875-881. 1999

Nivelul dovezii : 
Nivel de evidență C
Stabilitatea fizică : 
Examinare vizuala 
Stabilitate chimică : 
Cromatografia de lichide de inalta performanta cu detector in ultraviolet
Stabilitate definită ca si 95% din concentrația inițială
Alte metode : 
Măsurarea PH-ului 
Comentarii : 
Repetabilitatea / reproductibilitate / intervalul standard: rezultate neprevazute sau rezultate in afara valorilor specificate

Listele
InjectabilCarboplatin Citostatic
Compatibil 0.9 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilCimetidine hydrochloride Antihistaminic H2
Compatibil 5.76 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilCisplatin Citostatic
Compatibil 0.168 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilCyclophosphamide Citostatic
Compatibil 20 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilDexamethasone sodium phosphate Antiinflamator
Incompatibil 4 mg/ml + InjectabilTopotecan 0.056 mg/ml + Clorura de sodiu 0,9%
Compatibil 4 mg/ml + InjectabilTopotecan 0.056 mg/ml + Glucoza 5%
InjectabilDoxorubicin hydrochloride Citostatic
Compatibil 2 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilEtoposide Citostatic
Compatibil 0.4 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilFluorouracil Citostatic
Incompatibil 50 mg/ml + InjectabilTopotecan 0.056 mg/ml + Clorura de sodiu 0,9%
Compatibil 50 mg/ml + InjectabilTopotecan 0.056 mg/ml + Glucoza 5%
InjectabilGranisetron hydrochloride Antiemetic
Compatibil 0.02 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilIfosfamide Citostatic
Compatibil 14.28 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilMethylprednisolone sodium succinate Antiinflamator
Compatibil 2.4 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilMetoclopramide hydrochloride Antiemetic
Compatibil 1.72 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilMitomycin Citostatic
Incompatibil 0.084 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilOndansetron hydrochloride Antiemetic
Compatibil 0.48 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilPaclitaxel Citostatic
Compatibil 0.54 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilProchlorperazine edysilate Neuroleptic
Compatibil 0.192 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilTicarcillin / clavulanic acid Antibiotic
Compatibil 47.6/1.6 mg/ml + InjectabilTopotecan 0.056 mg/ml + Clorura de sodiu 0,9%
Incompatibil 47.6/1.6 mg/ml + InjectabilTopotecan 0.056 mg/ml + Glucoza 5%
InjectabilTopotecan Citostatic
Compatibil 0.056 mg/ml + InjectabilCarboplatin 0.9 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilCimetidine hydrochloride 5.76 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilCisplatin 0.168 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilCyclophosphamide 20 mg/ml + NaCl 0,9% sau Glucoza 5%
Incompatibil 0.056 mg/ml + InjectabilDexamethasone sodium phosphate 4 mg/ml + Clorura de sodiu 0,9%
Compatibil 0.056 mg/ml + InjectabilDexamethasone sodium phosphate 4 mg/ml + Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilDoxorubicin hydrochloride 2 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilEtoposide 0.4 mg/ml + NaCl 0,9% sau Glucoza 5%
Incompatibil 0.056 mg/ml + InjectabilFluorouracil 50 mg/ml + Clorura de sodiu 0,9%
Compatibil 0.056 mg/ml + InjectabilFluorouracil 50 mg/ml + Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilGranisetron hydrochloride 0.02 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilIfosfamide 14.28 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilMethylprednisolone sodium succinate 2.4 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilMetoclopramide hydrochloride 1.72 mg/ml + NaCl 0,9% sau Glucoza 5%
Incompatibil 0.056 mg/ml + InjectabilMitomycin 0.084 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilOndansetron hydrochloride 0.48 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilPaclitaxel 0.54 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilProchlorperazine edysilate 0.192 mg/ml + NaCl 0,9% sau Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilTicarcillin / clavulanic acid 47.6/1.6 mg/ml + Clorura de sodiu 0,9%
Incompatibil 0.056 mg/ml + InjectabilTicarcillin / clavulanic acid 47.6/1.6 mg/ml + Glucoza 5%
Compatibil 0.056 mg/ml + InjectabilVincristine sulfate 1 mg/ml + NaCl 0,9% sau Glucoza 5%
InjectabilVincristine sulfate Citostatic
Compatibil 1 mg/ml + InjectabilTopotecan 0.056 mg/ml + NaCl 0,9% sau Glucoza 5%
Stabilitatea in amestec
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Carboplatin 0,45 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Cimetidine hydrochloride 2,88 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Cisplatin 0,084 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Cyclophosphamide 10 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Doxorubicin hydrochloride 1 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Etoposide 0,2 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Granisetron hydrochloride 0,01 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Ifosfamide 7,14 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Methylprednisolone sodium succinate 1,2 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Metoclopramide hydrochloride 0,86 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Ondansetron hydrochloride 0,24 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Paclitaxel 0,27 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Prochlorperazine edysilate 0,096 mg/ml
4 Ora
Neprecizat NaCl 0,9% sau Glucoza 5% 20°C-23°C Lumina
Injectabil Topotecan 0,028 mg/ml
Injectabil Vincristine sulfate 0,5 mg/ml
4 Ora

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