Last update :
08/11/2024
References   References 800  
Type : Journal
Web link : https://doi.org/10.1177/106002809703100505

Research teams : Chicago - University of Illinois, College of Pharmacy
Authors : Fischer JH, Cwik MJ, Luer MS, Sibley CB, Deyo KL.
Title : Stability of fosphenytoin sodium with intravenous solutions in glass bottles, polyvinyl chloride bags, and polypropylene syringes.
Reference : Ann Pharmacotherapy ; 31: 553-559. 1997

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionFosphenytoin sodium Antiepileptic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1 & 8 & 20 mg/ml 25°C Not specified
30 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1 & 8 & 20 mg/ml 4°C Protect from light
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 8 & 20 mg/ml -20°C Protect from light
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 8 & 20 mg/ml 25°C Not specified
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 8 & 20 mg/ml 4°C Protect from light
30 Day
Stability in solutions Polypropylen Syringe None 50 mg/ml -20°C Light
30 Day
Stability in solutions Polypropylen Syringe None 50 mg/ml 25°C Not specified
30 Day
Stability in solutions Polypropylen Syringe None 50 mg/ml 4°C Protect from light
30 Day

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