Last update :
29/10/2024
References   References 4822  
Type : Journal
Web link : https://doi.org/10.1093/jacamr/dlae056

Research teams : Brisbane - The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia
Authors : Naicker S, Roberts J.A, Won H, Wallis S.C, Unwin S, Jamieson C, Hills T, Gilchrist M, Santillo M, Seaton R.A, Drummond F, Sime
Title : Evaluation of the stability of ceftazidime/avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy utilizing a national stability protocol framework.
Reference : JAC Antimicrob Resist 2024

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionCeftazidime Avibactam Antibiotic
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 6,25/1,56 >> 25/6,25 mg/ml 2-8°C Protect from light
3 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 6,25/1,56 >> 25/6,25 mg/ml 32°C Protect from light
12 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 6,25/1,56 >> 25/6,25 mg/ml 2-8°C Protect from light
3 Day
Stability in solutions Silicone elastomer Sodium chloride 0,9% 6,25/1,56 >> 25/6,25 mg/ml 32°C Protect from light
12 Hour

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