Last update :
19/11/2024
References   References 408  
Type : Journal

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Beijnen JH, Neef C, Meuwissen OJAT, Rutten JJMH, Rosing H, Underberg WJM.
Title : Stability of intravenous admixtures of doxorubicin and vincristine.
Reference : Am J Hosp Pharm ; 43: 3022-3027. 1986

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products

List of drugs
injectionDoxorubicin hydrochloride Anticancer drug
Compatible 1,4 mg/ml + injectionVincristine sulfate 0,033 mg/ml + Sodium chloride 0,9%
Compatible 1,4 mg/ml + injectionVincristine sulfate 0,033 mg/ml + NaCl 0,45% Glucose 2,5%
injectionVincristine sulfate Anticancer drug
Compatible 0,033 mg/ml + injectionDoxorubicin hydrochloride 1,4 mg/ml + Sodium chloride 0,9%
Compatible 0,033 mg/ml + injectionDoxorubicin hydrochloride 1,4 mg/ml + NaCl 0,45% Glucose 2,5%
Stability of mixtures
Polysiloxane Sodium chloride 0,9% 25°C Protect from light
injection Doxorubicin hydrochloride 1,4 mg/ml
injection Vincristine sulfate 0,033 mg/ml
14 Day
Polysiloxane Sodium chloride 0,9% 37°C Protect from light
injection Doxorubicin hydrochloride 1,4 mg/ml
injection Vincristine sulfate 0,033 mg/ml
7 Day
Polysiloxane NaCl 0,45% Glucose 2,5% 25°C Protect from light
injection Doxorubicin hydrochloride 1,4 mg/ml
injection Vincristine sulfate 0,033 mg/ml
14 Day
Polysiloxane NaCl 0,45% Glucose 2,5% 37°C Protect from light
injection Doxorubicin hydrochloride 1,4 mg/ml
injection Vincristine sulfate 0,033 mg/ml
7 Day

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