Last update :
19/11/2024
References   References 4061  
Type : Journal
Web link : https://ijpc.com/Abstracts/Abstract.cfm?ABS=4437

Research teams : Waltham - TESARO Inc, Waltham
Authors : Wu George, Powers Dan, Yeung S, Chen F, Neelon K.
Title : Compatibility and stability of VARUBI (Rolapitant) injectable emulsion admixed with intravenous granisetron hydrochloride.
Reference : Int J Pharm Compound ; 22,1 :86-94 2018

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
injectionGranisetron hydrochloride Antiemetic
Compatible 0.01 mg/ml + injectionRolapitant 1.8 mg/ml + None
injectionRolapitant Antiemetic
Compatible 1.8 mg/ml + injectionGranisetron hydrochloride 0.01 mg/ml + None
Stability of mixtures
Glass None 2-8°C Protect from light
injection Rolapitant 1,83 mg/ml
injection Granisetron hydrochloride 0,01 mg/ml
48 Hour
Glass None 20-25°C Light
injection Rolapitant 1,83 mg/ml
injection Granisetron hydrochloride 0,01 mg/ml
24 Hour

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