Last update :
08/11/2024
References   References 3998  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4349

Research teams : Angers - Institut de cancérologie de l’ouest - Paul Papin, Pharmacy Department
Authors : Robert J, Sorrieul J, Rossignol E, Beaussart H, Kieffer H, Folliard C, Dupoiron D, Devys C.
Title : Chemical Stability of Morphine, Ropivacaine, and Ziconotide in Combination for Intrathecal Analgesia.
Reference : Int J Pharm Compound ; 21:4 :347-351 2017

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Method not shown but the article refers to a validated method
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionMorphine sulfate Analgesic
injectionRopivacain hydrochloride Local anesthetic
injectionZiconotide acetate Analgesic
Stability of mixtures
Polyolefine Sodium chloride 0,9% 18-24°C Not specified
injection Morphine sulfate 2 mg/ml
injection Ropivacain hydrochloride 6 mg/ml
injection Ziconotide acetate 0,2 µg/ml
14 Day
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
injection Morphine sulfate 3,5 mg/ml
injection Ropivacain hydrochloride 7.5 mg/ml
injection Ziconotide acetate 1 µg/ml
3 Day

  Mentions Légales