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References   References 360  
Type : Journal
Research teams : Nagoya - Meijo University, Faculty of Pharmacy
Authors : Inagaki K, Gill MA, Okamoto MP, Takagi J.
Title : Stability of ranitidine hydrochloride with aztreonam, ceftazidime, or piperacillin sodium during simulated Y-site administration.
Reference : Am J Hosp Pharm ; 49: 2769-2772. 1992
Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection
List of drugs
injectionAztreonam Antibiotic
injectionCeftazidime Antibiotic
injectionPiperacillin sodium Antibiotic
injectionRanitidine hydrochloride Antihistamine (H2)
Stability of mixtures
Glass Not specified 23°C Light
injection Aztreonam 8,6 mg/ml
injection Ranitidine hydrochloride 0,5 mg/ml
4 Hour
Glass Not specified 23°C Light
injection Ceftazidime 10 mg/ml
injection Ranitidine hydrochloride 0,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Aztreonam 8,6 mg/ml
4 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Ceftazidime 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Piperacillin sodium 15 mg/ml
4 Hour
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