Last update :
19/11/2024
References   References 3279  
Type : Journal
Web link : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2011.01252.x/abstract

Research teams : Glasgow - Strathclyde Institute of Pharmacy and Biomedical Sciences
Authors : Al-Tannak N.F, Cable C.G, McArthur D.A, Watson D.G
Title : A stability indicating assay for a combination of morphine sulphate with levomepromazine hydrochloride used in palliative care.
Reference : J Clin Pharm Ther ; 37, 1: 71-73. 2012

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionLevomepromazine Neuroleptic
Factors which affect stability Temperature Increase Induces Degradation
Compatible + injectionMorphine sulfate + Water for Injection
injectionMorphine sulfate Analgesic
Compatible + injectionLevomepromazine + Water for Injection
Stability of mixtures
Polypropylene Water for Injection 37°C Not specified
injection Morphine sulfate 5,9 mg/ml
injection Levomepromazine 0,74 mg/ml
4 Hour

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