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References   References 3132  
Type : Journal
Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Negro S, Martin A, Azuara L, Sanchez Y, Barcia E.
Title : Compatibility and stability of ternary admixtures of tramadol, haloperidol, and hyoscine.
Reference : J Palliat Med ; 13, 3: 273-277. 2010
Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
Water loss by evaporation PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
injectionHaloperidol lactate Neuroleptic
injectionScopolamine N-butyl bromide Antimuscarinic
injectionTramadol hydrochloride Analgesic
Stability of mixtures
Not specified Sodium chloride 0,9% 25°C Protect from light
injection Scopolamine N-butyl bromide 3,33 >> 6,67 mg/ml
injection Tramadol hydrochloride 8,8 >> 33,3 mg/ml
injection Haloperidol lactate 0,208 >> 0,624 mg/ml
15 Day
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