Last update :
14/12/2024
References   References 3082  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/15/4/195

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
Title : Long-term stability of tramadol chlorhydrate and metoclopramide hydrochloride in dextrose 5% polyolefin bag at 4°C.
Reference : J Oncol Pharm Practice ; 15: 195-200. 2009

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionMetoclopramide hydrochloride Antiemetic
Compatible 0,1 mg/ml + injectionTramadol hydrochloride 1 mg/ml + Glucose 5%
injectionTramadol hydrochloride Analgesic
Compatible 1 mg/ml + injectionMetoclopramide hydrochloride 0,1 mg/ml + Glucose 5%
Stability of mixtures
Polyethylene Glucose 5% 4°C Protect from light
injection Metoclopramide hydrochloride 0,1 mg/ml
injection Tramadol hydrochloride 1 mg/ml
32 Day

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