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References   References 306  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/2/170
Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Christen C, Johnson CE, Walters JR.
Title : Stability of bupivacaine hydrochloride and hydromorphone hydrochloride during simulated epidural coadministration.
Reference : Am J Health-Syst Pharm ; 53: 170-173. 1996
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionBupivacaine hydrochloride Local anesthetic
Compatible 0,625 & 1,25 mg/ml + injectionHydromorphone hydrochloride 0,02 & 0,1 mg/ml + Sodium chloride 0,9%
injectionHydromorphone hydrochloride Analgesic
Compatible 0,02 & 0,1 mg/ml + injectionBupivacaine hydrochloride 0,625 & 1,25 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 23°C-25°C Light
injection Bupivacaine hydrochloride 0,62 & 1,2 mg/ml
injection Hydromorphone hydrochloride 0,02 & 0,1 mg/ml
72 Hour
  Mentions Légales