Last update :
19/11/2024
References   References 2369  
Type : Journal

Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Mason NA, Johnson CE, O'Brien MA.
Title : Stability of ceftazidime and tobramycin sulfate in peritoneal dialysis solution
Reference : Am J Hosp Pharm ; 49: 1139 - 1142. 1992

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
injectionCeftazidime Antibiotic
Compatible 0.125 mg/ml + injectionTobramycin sulfate 0.008 mg/ml + Dianéal® PD2 2.5% glucose (Baxter)
injectionTobramycin sulfate Antibiotic
Compatible 0.008 mg/ml + injectionCeftazidime 0.125 mg/ml + Dianéal® PD2 2.5% glucose (Baxter)
Stability of mixtures
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 24°C Not specified
injection Ceftazidime 0,125 mg/ml
injection Tobramycin sulfate 0,008 mg/ml
16 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 37°C Not specified
injection Ceftazidime 0,125 mg/ml
injection Tobramycin sulfate 0,008 mg/ml
8 Hour

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