Last update :
19/11/2024
References   References 2298  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2871

Research teams : San Francisco - Elan Pharmaceuticals Inc
Authors : Shields D.E, Aclan J, Szatkowski A.
Title : Chemical stability of admixtures containing ziconotide 25 mcg/ml and morphine sulfate 10 mg/ml or 20 mg/ml during simulated intrathecal administration.
Reference : Int J Pharm Compound ; 12, 6: 553-557. 2008

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Stability indicating capability inadequately assessed

List of drugs
injectionMorphine sulfate Analgesic
injectionZiconotide acetate Analgesic
Stability of mixtures
Not specified Sodium chloride 0,9% 37°C Protect from light
injection Ziconotide acetate 25 µg/ml
injection Morphine sulfate 20 mg/ml
19 Day
Not specified Sodium chloride 0,9% 37°C Protect from light
injection Ziconotide acetate 25 µg/ml
injection Morphine sulfate 10 mg/ml
34 Day
Not specified Sodium chloride 0,9% 5°C Protect from light
injection Ziconotide acetate 25 µg/ml
injection Morphine sulfate 20 mg/ml
28 Day
Not specified Sodium chloride 0,9% 5°C Protect from light
injection Ziconotide acetate 25 µg/ml
injection Morphine sulfate 10 mg/ml
60 Day

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