Last update :
08/11/2024
References   References 2251  
Type : Journal

Research teams : San Francisco - Elan Pharmaceuticals Inc
Authors : Shields D, Montenegro R, Ragusa M.
Title : Chemical stability of admixtures combining ziconotide with morphine or hydromorphone during simulated intrathecal administration.
Reference : Neuromodulation ; 8, 4: 257-263. 2005

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No visual inspection

List of drugs
injectionHydromorphone hydrochloride Analgesic
injectionMorphine sulfate Analgesic
injectionZiconotide acetate Analgesic
Stability of mixtures
Not specified Sodium chloride 0,9% 37°C Protect from light
injection Ziconotide acetate 25 µg/ml
injection Morphine sulfate 35 mg/ml
8 Day
Not specified Sodium chloride 0,9% 37°C Protect from light
injection Ziconotide acetate 25 µg/ml
injection Hydromorphone hydrochloride 35 mg/ml
19 Day

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